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题名	Development of a One-Step Synthesis of oxa-Spirocyclic Diphosphine Ligands Driven by Their Application in the Industrial Synthesis of Sacubitril
作者	Chen, Gen-Qiang1,2,3 ; Xiao, Renwei1 ; Ding, Xiaobing 1; Wang, Jiang1 ; Ma, Baode1 ; Lang, Qiwei 1; Zhang, Xumu1
通讯作者	Chen, Gen-Qiang; Lang, Qiwei; Zhang, Xumu
发表日期	2024-01-16
DOI	10.1021/acs.orglett.3c03536
发表期刊	ORGANIC LETTERS 影响因子和分区
ISSN	1523-7060
EISSN	1523-7052
卷号	26 期号:14
摘要	Herein we have developed a highly practical and efficient one-step coupling protocol for the synthesis of chiral spiro diphosphine ligands, especially for the oxa-spiro diphosphine ligands O-SDP, which showed excellent reactivity and diastereoselectivity in the asymmetric hydrogenation of a key intermediate of Sacubitril. It should be noted that the one-step coupling protocol could be operated on a kilogram scale, and the resulting ruthenium catalyst of O-SDP could hydrogenate the key intermediate of Sacubitril on an industrial scale.
相关链接	[来源记录]
收录类别	SCI ; IC
语种	英语
重要成果	NI期刊
学校署名	第一 ; 通讯
资助项目	National Natural Science Foundation of China[2021YFF0701604] ; National Key R&D Program of China[21991113] ; National Natural Science Foundation of China[KQTD20150717103157174] ; Shenzhen Science and Technology Innovation Committee[2022B1515020055] ; Southern University of Science and Technology[20200925161222002] ; Stable Support Plan Program of Shenzhen Natural Science Fund[2020B010188001] ; Key-Area Research and Development Program of Guangdong Province[2020KCXTD016]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:001162192600001
出版者	AMER CHEMICAL SOC
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	//www.snoollab.com/handle/2SGJ60CL/789079
专题	理学院_化学系前沿与交叉科学研究院
作者单位	1.Southern Univ Sci & Technol, Med X Pingshan & Dept Chem, Shenzhen 518000, Peoples R China 2.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China 3.Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China
第一作者单位	化学系; 前沿与交叉科学研究院;
通讯作者单位	化学系; 前沿与交叉科学研究院;
第一作者的第一单位	化学系
推荐引用方式 GB/T 7714	Chen, Gen-Qiang,Xiao, Renwei,Ding, Xiaobing,et al. Development of a One-Step Synthesis of oxa-Spirocyclic Diphosphine Ligands Driven by Their Application in the Industrial Synthesis of Sacubitril[J]. ORGANIC LETTERS,2024,26(14).
APA	Chen, Gen-Qiang.,Xiao, Renwei.,Ding, Xiaobing.,Wang, Jiang.,Ma, Baode.,...&Zhang, Xumu.(2024).Development of a One-Step Synthesis of oxa-Spirocyclic Diphosphine Ligands Driven by Their Application in the Industrial Synthesis of Sacubitril.ORGANIC LETTERS,26(14).
MLA	Chen, Gen-Qiang,et al."Development of a One-Step Synthesis of oxa-Spirocyclic Diphosphine Ligands Driven by Their Application in the Industrial Synthesis of Sacubitril".ORGANIC LETTERS 26.14(2024).