A bioadhesive pacing lead for atraumatic cardiac monitoring and stimulation in rodent and porcine models

Deng，Jue1; Wu，Jingjing1; Chen，Xiaoyu1; Sarrafian，Tiffany L.2; Varela，Claudia E.3; Whyte，William3; Guo，Chuan Fei4; Roche，Ellen T.1,3; Griffiths，Leigh G.5; Yuk，Hyunwoo1; Nabzdyk，Christoph S.6; Zhao，Xuanhe1,7

2024-06-19

10.1126/scitranslmed.ado9003

Science translational medicine   影响因子和分区

1946-6242

Current clinically used electronic implants, including cardiac pacing leads for epicardial monitoring and stimulation of the heart, rely on surgical suturing or direct insertion of electrodes to the heart tissue. These approaches can cause tissue trauma during the implantation and retrieval of the pacing leads, with the potential for bleeding, tissue damage, and device failure. Here, we report a bioadhesive pacing lead that can directly interface with cardiac tissue through physical and covalent interactions to support minimally invasive adhesive implantation and gentle on-demand removal of the device with a detachment solution. We developed 3D-printable bioadhesive materials for customized fabrication of the device by graft-polymerizing polyacrylic acid on hydrophilic polyurethane and mixing with poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) to obtain electrical conductivity. The bioadhesive construct exhibited mechanical properties similar to cardiac tissue and strong tissue adhesion, supporting stable electrical interfacing. Infusion of a detachment solution to cleave physical and covalent cross-links between the adhesive interface and the tissue allowed retrieval of the bioadhesive pacing leads in rat and porcine models without apparent tissue damage. Continuous and reliable cardiac monitoring and pacing of rodent and porcine hearts were demonstrated for 2 weeks with consistent capture threshold and sensing amplitude, in contrast to a commercially available alternative. Pacing and continuous telemetric monitoring were achieved in a porcine model. These findings may offer a promising platform for adhesive bioelectronic devices for cardiac monitoring and treatment.

英语

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其他

2-s2.0-85196682802

Scopus

1.Department of Mechanical Engineering,Massachusetts Institute of Technology,Cambridge,02139,United States
2.Department of Thoracic Surgery,Mayo Clinic,Rochester,United States
3.Institute for Medical Engineering and Science,Massachusetts Institute of Technology,Cambridge,MA 02139,United States
4.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
5.Department of Cardiovascular Medicine,Mayo Clinic,Rochester,United States
6.Department of Anesthesiology and Perioperative Medicine,Mayo Clinic,Rochester,United States
7.Department of Civil and Environmental Engineering,Massachusetts Institute of Technology,Cambridge,MA 02139,United States

Deng，Jue,Wu，Jingjing,Chen，Xiaoyu,et al. A bioadhesive pacing lead for atraumatic cardiac monitoring and stimulation in rodent and porcine models[J]. Science translational medicine,2024,16(752).

Deng，Jue.,Wu，Jingjing.,Chen，Xiaoyu.,Sarrafian，Tiffany L..,Varela，Claudia E..,...&Zhao，Xuanhe.(2024).A bioadhesive pacing lead for atraumatic cardiac monitoring and stimulation in rodent and porcine models.Science translational medicine,16(752).

Deng，Jue,et al."A bioadhesive pacing lead for atraumatic cardiac monitoring and stimulation in rodent and porcine models".Science translational medicine 16.752(2024).