Chromium Nanoparticles Improve Macrophage and T Cell Infiltration for Cancer Immunotherapy

Liu，Quan1,3; Sun，Zhe1,2; Duo，Yanhong4; Yin，Lei3; Lv，Kongpeng5; Yue，Ludan2; Meng，Qian Fang2; Nie，Dingmeng2; Chen，Jiaojuan1; Luo，Dixian3; Liu，Li Ping1; Rao，Lang2

2023-06-05

10.1021/acsmaterialslett.2c01136

ACS Materials Letters   影响因子和分区

2639-4979

Immune checkpoint blockade has been regarded as a highly promising cancer immunotherapy approach. However, inefficient immune cell infiltration and the immunosuppressive tumor microenvironment (TME) remain significant causes of low clinical response rates. Here, we identified that trivalent chromium irons (Cr) could enhance tumor infiltration of immune cells including M1-type tumor-associated macrophages and CD8 T cells. Mechanistically, this effect is dependent on the expression of macrophage inflammatory protein-1α (MIP-1α) and the PI3K/Akt/mTOR pathway. Moreover, the Cr-based nanoparticles (Cr NPs) exhibited superior photothermal properties under near-infrared laser irradiation, showing great potential in transforming “cold” tumors into “hot” ones. In combination with the PD-1/PD-L1 pathway inhibitor, we demonstrated that the Cr NPs significantly improved anticancer efficacy in mouse models of hepatoma and melanoma by increasing antitumor immune cell infiltration and relieving immunosuppressive TME. Overall, the Cr NPs offer a new dual-functional platform for local and systemic cancer treatments, paving the way toward cancer photometalloimmunotherapy.

SCI

英语

第一

National Natural Science Foundation of China["82272779","82273236","82222035","82003036"] ; Guangdong Basic and Applied Basic Research Foundation["2021A1515220059","2021A1515111036","2022A1515110308","2023A1515030182"] ; Science and Technology Innovation Commission of Shenzhen["JCYJ20190806160412946","JCYJ20220530141608020"] ; Shenzhen Bay Laboratory Startup Fund[21310071]

Materials Science

Materials Science, Multidisciplinary

WOS:001004846900001

AMER CHEMICAL SOC

2-s2.0-85161010640

Scopus

1.Division of Hepatobiliary and Pancreas Surgery,Department of General Surgery,Shenzhen People’s Hospital,(The Second Clinical Medical College,Jinan University,and The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518020,China
2.Institute of Biomedical Health Technology and Engineering,Shenzhen Bay Laboratory,Shenzhen,518132,China
3.Department of Laboratory Medicine,Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital),Shenzhen University,Shenzhen,518052,China
4.Department of Microbiology,Tumor and Cell Biology (MTC),Karolinska Institutet,Stockholm,17177,Sweden
5.Department of Interventional Radiology,Shenzhen People’s Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,518020,China

Liu，Quan,Sun，Zhe,Duo，Yanhong,et al. Chromium Nanoparticles Improve Macrophage and T Cell Infiltration for Cancer Immunotherapy[J]. ACS Materials Letters,2023,5(6):1738-1751.

Liu，Quan.,Sun，Zhe.,Duo，Yanhong.,Yin，Lei.,Lv，Kongpeng.,...&Rao，Lang.(2023).Chromium Nanoparticles Improve Macrophage and T Cell Infiltration for Cancer Immunotherapy.ACS Materials Letters,5(6),1738-1751.

Liu，Quan,et al."Chromium Nanoparticles Improve Macrophage and T Cell Infiltration for Cancer Immunotherapy".ACS Materials Letters 5.6(2023):1738-1751.