Macrophages in immunoregulation and therapeutics

Chen, Shanze1,2,3; Saeed, Abdullah F. U. H.4; Liu, Quan5; Jiang, Qiong1,2,3; Xu, Haizhao1,2,3,6; Xiao, Gary Guishan7; Rao, Lang8; Duo, Yanhong9

2023-05-22

10.1038/s41392-023-01452-1

SIGNAL TRANSDUCTION AND TARGETED THERAPY   影响因子和分区

2095-9907

2059-3635

Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers. Macrophages possess binary M1/M2 macrophage polarization settings, which perform a central role in an array of immune tasks via intrinsic signal cascades and, therefore, must be precisely regulated. Many crucial questions about macrophage signaling and immune modulation are yet to be uncovered. In addition, the clinical importance of tumor-associated macrophages is becoming more widely recognized as significant progress has been made in understanding their biology. Moreover, they are an integral part of the tumor microenvironment, playing a part in the regulation of a wide variety of processes including angiogenesis, extracellular matrix transformation, cancer cell proliferation, metastasis, immunosuppression, and resistance to chemotherapeutic and checkpoint blockade immunotherapies. Herein, we discuss immune regulation in macrophage polarization and signaling, mechanical stresses and modulation, metabolic signaling pathways, mitochondrial and transcriptional, and epigenetic regulation. Furthermore, we have broadly extended the understanding of macrophages in extracellular traps and the essential roles of autophagy and aging in regulating macrophage functions. Moreover, we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and tumorigenesis. Lastly, we discussed targeted macrophage therapy to portray prospective targets for therapeutic strategies in health and diseases.

SCI

英语

ESI热点 ; ESI高被引

其他

National Natural Science Foundation of China["81803183","82272779","82003036","82273236"] ; National Key R&D Program of China["2022YFF0710800","2022YFF0710802"] ; Natural Science Foundation of Sichuan province, China[2019YFS0230] ; Science and Technology Innovation Commission of Shenzhen[JCYJ20220530141608020] ; Natural Science Foundation of Guangdong province, China["2214050008970","2019A1515012079"] ; Guangdong Basic and Applied Basic Research Foundation[2023A1515030182]

Biochemistry & Molecular Biology ; Cell Biology

Biochemistry & Molecular Biology ; Cell Biology

WOS:000993248000002

SPRINGERNATURE

2-s2.0-85160112173

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Affiliated Hosp 1,Shenzhen Inst Resp Dis, Shenzhen 518020, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Crit Care Unit,Shenzhen Inst Resp Dis, Shenzhen 518020, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Peoples R China
4.City Hope Natl Med Ctr, Beckman Res Inst, Dept Canc Biol, Los Angeles, CA 91010 USA
5.Shenzhen Univ, Huazhong Univ Sci & Technol, Union Shenzhen Hosp, Nanshan Hosp,Dept Lab Med, Shenzhen 518052, Peoples R China
6.Southern Univ Sci & Technol, Affiliated Hosp 1, Sch Med, Dept Resp, Shenzhen 518055, Peoples R China
7.Dalian Univ Technol, Sch Chem Engn, Dept Pharmaceut Sci, State Key Lab Fine Chem, Dalian, Peoples R China
8.Shenzhen Bay Lab, Inst Biomed Hlth Technol & Engn, Shenzhen 518132, Peoples R China
9.Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Stockholm, Sweden

Chen, Shanze,Saeed, Abdullah F. U. H.,Liu, Quan,et al. Macrophages in immunoregulation and therapeutics[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2023,8(1).

Chen, Shanze.,Saeed, Abdullah F. U. H..,Liu, Quan.,Jiang, Qiong.,Xu, Haizhao.,...&Duo, Yanhong.(2023).Macrophages in immunoregulation and therapeutics.SIGNAL TRANSDUCTION AND TARGETED THERAPY,8(1).

Chen, Shanze,et al."Macrophages in immunoregulation and therapeutics".SIGNAL TRANSDUCTION AND TARGETED THERAPY 8.1(2023).