Tuning protein adsorption on charged polyelectrolyte brushes via salinity adjustment

Han, Linbo1; Yan, Bin1,2; Zhang, Ling1; Wu, Min1; Wang, Jingyi1; Huang, Jun1; Deng, Yonghong3; Zeng, Hongbo1

2018-02-20

10.1016/j.colsurfa.2017.12.004

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS   影响因子和分区

0927-7757

1873-4359

Adsorption and desorption of biomolecules on/from polyelectrolyte surfaces play a critical role in numerous biomedical and engineering applications. Though some weak polyelectrolytes have been developed for protein adsorption and desorption by regulating the salinity and pH, limited reports are available about the regeneration of strong polyelectrolyte surfaces between protein-attractive and protein-repulsive states, which is highly desirable but challenging to realize as it is more difficult to fully release the pre-adsorbed proteins from strong polyelectrolytes due to their permanent charges comparing to weak polyelectrolytes. Here we report a strategy to facilely tune the resistance to nonspecific protein adsorption onto a charged cationic poly([2-(methacryloyloxy)ethyl] trimethylammonium chloride (PMTAC) or anionic Poly(3-sulfopropyl methacrylate potassium salt) (PSPMA)) strong polyelectrolyte brush coating via salinity adjustment. It has been demonstrated that the charged polyelectrolyte coating displays strong adhesion to proteins at low salinity (e.g., 0.1 mM NaCl) but proteinre-pellent property at high salinity (e.g., 1.0 M NaCl). The adsorbed proteins on the strong polyelectrolyte coatings under low salinity condition could be readily removed via rinsing with high-salinity water, demonstrating the excellent surface regeneration capability.

Polyelectrolyte brush Controllable adsorption Surface forces Antifouling Adhesion

SCI ; EI

英语

通讯

China Scholarship Council[] ; Alberta Innovates - Technology Futures[] ; Natural Sciences and Engineering Research Council of Canada[] ; Canada Research Chairs[]

Chemistry

Chemistry, Physical

WOS:000424953600005

ELSEVIER SCIENCE BV

20174904507151

Adhesion ; Adsorption ; Coatings ; Desorption ; Potassium chloride ; Proteins ; Sodium chloride

Chemical Operations:802.3 ; Organic Compounds:804.1 ; Coating Materials:813.2 ; Organic Polymers:815.1.1 ; Materials Science:951

CHEMISTRY

Web of Science

1.Univ Alberta, Chem & Mat Engn, Edmonton, AB T6G 2V4, Canada
2.Sichuan Univ, Coll Light Ind Text & Food Engn, Chengdu 610065, Sichuan, Peoples R China
3.South Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen, Peoples R China

Han, Linbo,Yan, Bin,Zhang, Ling,et al. Tuning protein adsorption on charged polyelectrolyte brushes via salinity adjustment[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2018,539:37-45.

Han, Linbo.,Yan, Bin.,Zhang, Ling.,Wu, Min.,Wang, Jingyi.,...&Zeng, Hongbo.(2018).Tuning protein adsorption on charged polyelectrolyte brushes via salinity adjustment.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,539,37-45.

Han, Linbo,et al."Tuning protein adsorption on charged polyelectrolyte brushes via salinity adjustment".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 539(2018):37-45.