MiR-22-3p suppresses cell growth via MET/STAT3 signaling in lung cancer

Yang，Xia1; Su，Wenmei2; Li，Yu3; Zhou，Zhiqing3; Zhou，Yi3; Shan，Hu1; Han，Xiaoling2; Zhang，Ming1; Zhang，Qiuhong1; Bai，Ying1; Guo，Chunfang4; Yang，Shuanying1; Beer，David G.4; Chen，Guoan3

2021

American Journal of Translational Research   影响因子和分区

1943-8141

1943-8141

MiR-22-3p has been reported to be down-regulated in several cancers, but its expression pattern and roles in lung cancer is unclear. Given the crucial role of microRNAs in cancer progression, we examined the expression and function of miR-22-3p in lung adenocarcinoma. MiR-22-3p expression in lung cancer tissues and cell lines was measured by qRT-PCR. Cell proliferation was measured by WST-1 and colony formation assays were used to reveal the role of miR-22-3p in lung cancer in vitro. MiR-22-3p was notably down-regulated in lung cancer tissues as compared to normal lung tissues, but it was not associated with the clinical characteristics of tumor stage, differentiation and patient's smoking status. Colony formation ability and cell proliferation were suppressed by miR-22-3p mimics in lung cancer cell lines. Mechanistically, miR-22-3p mimics could reduce MET and STAT3 protein expression and induce apoptosis as measured by PARP protein. We conclude that miR-22-3p may play a tumor suppressor role via inhibiting MET-STAT3 signaling and have potential to be a therapeutic target and biomarker in lung adenocarcinoma.

Lung cancer MET MiR-22-3p STAT3

SCI

英语

通讯

National Natural Science Foundation of China (NSFC)[32070625,81702270] ; Affiliated Hospital of Guangdong Medical University Doctoral Foundation[2018052638] ; General Project of Key Research and Development Program of Shaanxi Province[2017SF-173]

Oncology ; Research & Experimental Medicine

Oncology ; Medicine, Research & Experimental

WOS:000643495900008

E-CENTURY PUBLISHING CORP

2-s2.0-85102879179

Scopus

1.Department of Respiratory and Critical Care Medicine,The Second Affiliated Hospital of xi'An Jiaotong University,Xi'an,China
2.Department of Oncology,Affiliated Hospital of Guangdong Medical University,Zhanjiang,China
3.School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China
4.Department of Surgery,University of Michigan,Ann Arbor,United States

Yang，Xia,Su，Wenmei,Li，Yu,et al. MiR-22-3p suppresses cell growth via MET/STAT3 signaling in lung cancer[J]. American Journal of Translational Research,2021,13(3):1221-1232.

Yang，Xia.,Su，Wenmei.,Li，Yu.,Zhou，Zhiqing.,Zhou，Yi.,...&Chen，Guoan.(2021).MiR-22-3p suppresses cell growth via MET/STAT3 signaling in lung cancer.American Journal of Translational Research,13(3),1221-1232.

Yang，Xia,et al."MiR-22-3p suppresses cell growth via MET/STAT3 signaling in lung cancer".American Journal of Translational Research 13.3(2021):1221-1232.