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题名	Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19
作者	Silvin，Aymeric 1; Chapuis，Nicolas 2,3; Dunsmore，Garett 1; Goubet，Anne Gaëlle 1; Dubuisson，Agathe 1; Derosa，Lisa 1,4; Almire，Carole 3; Hénon，Clémence 5; Kosmider，Olivier 2,3; Droin，Nathalie 6,7; Rameau，Philippe 7; Catelain，Cyril 7; Alfaro，Alexia 7; Dussiau，Charles 2,3; Friedrich，Chloé 2,3; Sourdeau，Elise 8; Marin，Nathalie 9; Szwebel，Tali Anne 10; Cantin，Delphine 8; Mouthon，Luc 2,10; Borderie，Didier 11; Deloger，Marc 7; Bredel，Delphine 1; Mouraud，Severine 1; Drubay，Damien 12; Andrieu，Muriel 2; Lhonneur，Anne Sophie 13; Saada，Véronique 14; Stoclin，Annabelle 15; Willekens，Christophe 6,16; Pommeret，Fanny 4; Griscelli，Frank 4,14; Ng，Lai Guan 17; Zhang，Zheng 18 ; Bost，Pierre 19,20; Amit，Ido 20; Barlesi，Fabrice 4; Marabelle，Aurélien 1,21; Pène，Frédéric 2,9; Gachot，Bertrand 15; André，Fabrice 4,5,22; Zitvogel，Laurence 1,22,23; Ginhoux，Florent 17,24,25; Fontenay，Michaela 2,3; Solary，Eric 6,15,22
通讯作者	Ginhoux，Florent
发表日期	2020-09-17
DOI	10.1016/j.cell.2020.08.002
发表期刊	CELL 影响因子和分区
ISSN	0092-8674
EISSN	1097-4172
卷号	182 期号:6页码:1401-1418.e18
摘要	An analysis of patients with severe COVID-19 reveals immature neutrophil and non-classical monocyte pools, with levels of the protein calprotectin linked to disease severity.
关键词	calprotectin COVID-19 emergency myelopoiesis monocyte subsets neutrophils S100A8 S100A9 SARS-CoV-2 type I interferon
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
重要成果	NI期刊 ; NI论文 ; ESI高被引
学校署名	其他
资助项目	Singapore National Research Foundation Senior Investigatorship (NRFI)[NRF2016NRF-NRFI001-02]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000571443300008
出版者	CELL PRESS
ESI学科分类	MOLECULAR BIOLOGY & GENETICS
Scopus记录号	2-s2.0-85089528043
来源库	Scopus
引用统计	被引频次[WOS]：531
成果类型	期刊论文
条目标识符	//www.snoollab.com/handle/2SGJ60CL/184681
专题	医学院第二附属医院
作者单位	1.INSERM U1015,Gustave Roussy Cancer Campus,Villejuif,94800,France 2.Université de Paris,Institut Cochin,CNRS UMR8104,INSERM U1016,Paris,75006,France 3.Service d'Hématologie Biologique,AP-HP,hôpital Cochin,Paris,75014,France 4.Département d'Oncologie Médicale,Gustave Roussy Cancer Campus,Villejuif,94800,France 5.INSERM U981,Gustave Roussy Cancer Campus,Villejuif,94800,France 6.INSERM U1287,Gustave Roussy Cancer Campus,Villejuif,94800,France 7.INSERM US23,CNRS UMS 3655,Gustave Roussy Cancer Campus,Villejuif,94800,France 8.Service des Urgences,AP-HP,hôpital Hôtel-Dieu,Paris,75014,France 9.Service de Médecine Intensive et Réanimation,AP-HP,hôpital Cochin,Paris,75014,France 10.Service de Médecine Interne,AP-HP,hôpital Cochin,Paris,75014,France 11.Service de Diagnostic Biologique Automatisé,AP-HP,hôpital Cochin,Paris,75014,France 12.INSERM U1018,Gustave Roussy Cancer Campus,Villejuif,94800,France 13.Laboratoire de Virologie,AP-HP,hôpital Cochin,Paris,75014,France 14.Département de Biologie et Pathologie,Gustave Roussy Cancer Campus,Villejuif,94800,France 15.Service de Réanimation Médicale,Gustave Roussy Cancer Campus,Villejuif,94800,France 16.Département d'Hématologie,Gustave Roussy Cancer Campus,Villejuif,94800,France 17.Singapore Immunology Network (SIgN),Agency for Science,Technology and Research (ASTAR),8A Biomedical Grove,Immunos Building #3–4,Biopolis,Singapore,138648,Singapore 18.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,518112,China 19.Systems Biology Group,Department of Computational Biology and USR 3756,Institut Pasteur and CNRS,Paris,75015,France 20.Department of Immunology,Weizmann Institute of Science,Rehovot,Israel 21.Département d'Innovation Thérapeutique et d'Essais Précoces (DITEP),Gustave Roussy Cancer Campus,Villejuif,94800,France 22.Université Paris-Saclay,faculté de Médecine,Le Kremlin-Bicêtre,94270,France 23.Centre d'Investigation Clinique – Biothérapie,INSERM CICBT1428,Villejuif,94800,France 24.Shanghai Institute of Immunology,Shanghai JiaoTong University School of Medicine,Shanghai,280 South Chongqing Road,200025,China 25.Translational Immunology Institute,SingHealth Duke-NUS Academic Medical Centre,Singapore,169856,Singapore
推荐引用方式 GB/T 7714	Silvin，Aymeric,Chapuis，Nicolas,Dunsmore，Garett,et al. Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19[J]. CELL,2020,182(6):1401-1418.e18.
APA	Silvin，Aymeric.,Chapuis，Nicolas.,Dunsmore，Garett.,Goubet，Anne Gaëlle.,Dubuisson，Agathe.,...&Solary，Eric.(2020).Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19.CELL,182(6),1401-1418.e18.
MLA	Silvin，Aymeric,et al."Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19".CELL 182.6(2020):1401-1418.e18.